The third head of the family, Jiroemon Noshie,started manufacturing the colorant of red iron oxide from melanterite using the ore from the Roha mountains. It is said that,after years of trial and error,he succeeded in producting red colorant for painting chinaware which was beetter in quality than other foreign-made puroduct. Still, the quantities produceed were small at that time. In 1751, the sixth head of the family, Heiemon Nishie,together with an engineer Yahachi Hara, succeeded in mass-production of melanterie(or Roha) in good quality. In 1754, an illustracted book about industrial techniques for daily commodities named Nihon Sankai Meibutsu Zue introduceed the high quality melantrite as one of the ointment ingredients,and the lower quality one as colorant and pigment, both of whose main production region was Bicchu Roha-Yama(Melanterite Mountains in Bicchu area) In Meiji and  Taisho Eras (late 19th century -early 20th century) the product eon all the prizes in expositions and fairs around the nation. The distributuin route was broadend and the market spread as far as to Western Europe. The 13th head of the family , Gen-ichi Nishie, and other local capitalists created jobs

and gained enormous wealth.